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Flawless Internet, LLC was founded in October 2011 by Neal O'Farrell. Neal is a recognized expert in the field of Web application security, mobile application security, risk analysis, penetration testing and ethical hacking. Neal is a frequent speaker at industry conferences, a contributing editor and guest contributor to several magazines and journals, a member of the Information Systems Audit and Control Association (ISACA), and serves as a reviewer of books for O'Reilly and other publishers. Visit Neal's web site, nealofarrell.com, to read Neal's articles, view Neal's past presentations, and watch Neal's videos. Follow Neal on Twitter, @nealofarrell.Electrical activity of the rat femoral artery during aging.
In order to evaluate the potential for a change in the electrical activity of the femoral artery (FA) with aging, we examined the response to a step change in transmural pressure of the rat FA to study the maximum contraction of smooth muscle to KCl and the activation of membrane potential oscillation in the presence of the Ca2+ channel blockers Cd2+ and Ni2+. The vascular smooth muscle was prepared from the FA of 8-week-old and 21-month-old male Wistar rats and its contractile response to cumulative KCl (60 mM) was examined. The addition of Cd2+ and Ni2+ to the superfusing solution significantly shifted the dose-response curve of KCl in a leftward direction. With cumulative KCl, the response of the FA in the 21-month-old rats (mean +/- SE) was significantly decreased compared with that of the FA of the 8-week-old rats (mean +/- SE): the maximum contraction to KCl was 74.9 +/- 8.8% and 104.0 +/- 4.2%, respectively. In the presence of Cd2+ and Ni2+, the FA from the 21-month- 0b46394aab